Yamamoto T, Katayama I, Nishioka K
Department of Dermatology, Tokyo Medical and Dental University School of Medicine.
Nihon Rinsho. 1995 Nov;53(11):2759-63.
Perifollicular fibroma (PF) is a cutaneous hamartomatous proliferation of the pilar connective tissue sheath. It occurs predominantly on the face or neck in a solitary or multiple form. Histologically, it is characterized by a concentric arrangement of collagen fibers surrounding hair follicles. Other related proliferations include fibrofolliculoma and trichodiscoma, which are often complicated or have histological overlapping features, so they may represent the same spectrum of pilar mesodermal proliferation. Some individuals with multiple PFs have colonic polyposis, some of which develop into carcinomas, and there are suggestions of autosomal dominant inheritance. It appears that patients with multiple PFs and/or other connective tissue hamartomas may be at risk for colonic polyposis. Cutaneous signs may lead to an early discovery of digestive diseases.
毛囊周围纤维瘤（PF）是一种毛囊结缔组织鞘的皮肤错构瘤性增生。它主要以单发或多发形式出现在面部或颈部。组织学上，其特征是围绕毛囊的胶原纤维呈同心圆排列。其他相关增生包括纤维毛囊瘤和毛发上皮瘤，它们常合并存在或具有组织学重叠特征，因此可能代表毛囊中胚层增生的同一谱系。一些患有多发性PF的个体有结肠息肉病，其中一些会发展为癌，提示存在常染色体显性遗传。似乎患有多发性PF和/或其他结缔组织错构瘤的患者可能有患结肠息肉病的风险。皮肤体征可能有助于早期发现消化系统疾病。
