大鼠股动脉血管滋养血管形态的年龄相关变化

Age-related alterations in the morphology of femoral artery vasa vasorum in the rat.

作者信息

Phillips G D, Stone A M, Schultz J C, Whitehead R A, Jones B D, Goodkin M L, Ruebel M W, Knighton D R

机构信息

University of Minnesota, Department of Surgery, Minneapolis 55455, USA.

出版信息

Mech Ageing Dev. 1995 Aug 8;82(2-3):149-54. doi: 10.1016/0047-6374(95)01604-x.

DOI:10.1016/0047-6374(95)01604-x

PMID:8538243

Abstract

The objective of this study was to explore any age-related morphological changes in the vasa vasorum of the rat femoral artery. Vascular corrosion casts were prepared from 2, 12 and 24-month-old rats. Examination of the casts with the scanning electron microscope revealed dramatic differences in the appearance of the vessels of young and aged rats. The vasa vasorum of 2-month-old rats consisted of a dense network of capillaries. These vessels were dramatically reduced in number by 12 months, and even fewer capillaries were present at 24 months. This reduction in capillary density is consistent with the observed age-related decreases in oxygen tension and may explain why the aged are more prone to atherosclerosis.

摘要

本研究的目的是探讨大鼠股动脉血管滋养血管中与年龄相关的形态学变化。制备了2个月、12个月和24个月大的大鼠的血管铸型。用扫描电子显微镜检查铸型发现，年轻大鼠和老年大鼠血管外观存在显著差异。2个月大的大鼠的血管滋养血管由密集的毛细血管网络组成。到12个月时，这些血管的数量显著减少，到24个月时毛细血管更少。毛细血管密度的这种降低与观察到的与年龄相关的氧张力降低一致，这可能解释了为什么老年人更容易患动脉粥样硬化。