Vasconcellos C, Domingues P P, Aoki V, Miyake R K, Sauaia N, Martins J E
School of Medicine, University of S. Paulo, Brazil.
Rev Saude Publica. 1995 Jun;29(3):177-82. doi: 10.1590/s0034-89101995000300004.
The profile of 247 patients with erythroderma during a 23 year period from January, 1962 through March, 1985, with a follow-up period ranging from 1 to 26 years were analysed. The patients presented with diffuse erythema, scaling and pruritus of more than 2 months' duration, and the age ranged from 16 to 60 years. Psoriasis was the most frequent underlying disease with an estimated frequency of 44.9%, the reaction to the use of drugs appeared in 7.3% of total cases and association with reticulosis showed a frequency of 4.1%. The cause of the erythroderma could not be determined in 29.2% of the cases. Six differences in terms of underlying diseases were not observed. One or more skin biopsies along with clinical findings were diagnostic or suggestive of the underlying disease in 63.6% of the cases. Repeated skin biopsies are recommended as the best method for etiologic diagnosis of erythroderma. At P = 0.05 significance level, masculine/feminine ratio of 2:1 was found. The question arises whether causal agent of erythroderma may not be somehow related to different exposure by sex to environmental antigens.
分析了1962年1月至1985年3月这23年间247例红皮病患者的资料，随访时间为1至26年。患者表现为弥漫性红斑、脱屑和瘙痒，病程超过2个月，年龄在16至60岁之间。银屑病是最常见的基础疾病，估计发生率为44.9%，药物使用反应占总病例的7.3%，与网状细胞增多症相关的发生率为4.1%。29.2%的病例无法确定红皮病的病因。未观察到基础疾病方面的六个差异。63.6%的病例通过一次或多次皮肤活检及临床发现可诊断或提示基础疾病。建议重复进行皮肤活检作为红皮病病因诊断的最佳方法。在P = 0.05显著性水平下，发现男性/女性比例为2:1。由此产生一个问题，即红皮病的致病因素是否可能与不同性别对环境抗原的不同暴露有关。
