Barron P, Goobi P, Davies J, Pye S, Radziuk J
Ottawa Civic Hospital, Ontario, Canada.
Transplant Proc. 1995 Dec;27(6):3040-1.
It has been previously noted that a mild insulin deficiency could increase insulin sensitivity in rats. The data shown here are consistent with such an observation in that the insulin resistance, which was induced by diversion of pancreatic venous drainage to the peripheral circulation, was corrected by the insulin deficiency which was secondary to the hemipancreatectomy performed. These results also help to explain some of the apparent inconsistencies that appear to be present in the comparison often made of insulin sensitivity following various transplantation procedures. Both the site of pancreatic venous drainage and any decrease in beta-cell mass which may accompany pancreas or islet transplantation appear to have independent and opposite effects on insulin sensitivity.
先前已经注意到，轻度胰岛素缺乏可增加大鼠的胰岛素敏感性。此处所示数据与这一观察结果一致，即通过将胰静脉引流转向外周循环诱导的胰岛素抵抗，可通过继发于半胰切除术的胰岛素缺乏得到纠正。这些结果也有助于解释在各种移植手术后胰岛素敏感性比较中经常出现的一些明显不一致之处。胰静脉引流部位以及胰腺或胰岛移植可能伴随的β细胞量减少，似乎对胰岛素敏感性具有独立且相反的作用。
