Constantinides C, Pavlaki K, Zizi D, Gavriel J, Mitropoulos D, Garifalos J, Dimopoulos C
Department of Urology, Athens University Medical School, Greece.
Urol Int. 1995;55(3):134-6. doi: 10.1159/000282769.
Specimens from 75 cases of prostatic adenocarcinoma of different M.D. Anderson degrees of malignancy were stained immunohistochemically for neuron-specific enolase (NSE), prostatic specific antigen (PSA) and prostatic acid phosphatase (PAP). None of these tumors presented on hematoxylineosin sections any features suggesting neuroendocrine differentiation; nevertheless, 18.7% of the tumors were at least focally NSE positive. Because of the synchronous antigenic expression of the NSE-positive cells to PSA and PAP, the authors suggest that prostatic exocrine and neuroendocrine cells derive from a common precursor stem cell. The possibility of a more aggressive biological behavior of these tumors in comparison to the conventional carcinomas is discussed. The probable clinical necessity for a combined therapeutic approach is also investigated.
对75例不同恶性程度的前列腺腺癌标本进行免疫组织化学染色，检测神经元特异性烯醇化酶（NSE）、前列腺特异性抗原（PSA）和前列腺酸性磷酸酶（PAP）。这些肿瘤在苏木精-伊红切片上均未呈现提示神经内分泌分化的特征；然而，18.7%的肿瘤至少局灶性NSE阳性。由于NSE阳性细胞与PSA和PAP同步抗原表达，作者认为前列腺外分泌细胞和神经内分泌细胞来源于共同的前体干细胞。讨论了这些肿瘤与传统癌相比具有更具侵袭性生物学行为的可能性。还研究了联合治疗方法可能的临床必要性。
