Guthrie A J, Beadle R E, Bateman R D, White C E
Department of Veterinary Physiology, Pharmacology and Toxicology, Louisiana State University, Baton Rouge 70803, USA.
Vet Res Commun. 1995;19(4):331-42. doi: 10.1007/BF01839315.
The purpose of this study was to characterize the normal equine tidal breathing flow-volume loop (TBFVL). The study was performed using 18 healthy Thoroughbred horses. TBFVLs constructed from data collected from resting horses had a typical biphasic inspiratory and expiratory phase. The interindividual variability of the indices used to describe TBFVLs was in the range 16-32%, which is comparable to the variability of other measures of equine pulmonary mechanics. The large variability of these data probably limits the value of resting TBFVL indices for detecting subclinical respiratory conditions in individual horses. Factor analysis of these data revealed that in excess of 90% of the variance of the initial response variables could be explained in terms of three common factors. Varimax rotation of these three common factors provided three subsequent factors that were readily identifiable as (1) a factor describing the time-volume relationships of TBFVLs, responsible for 81% of the total variance, (2) a factor explaining the expiratory portion of the TBFVL, explaining 12% of the variance, and (3) a factor describing the inspiratory portion of the loops, responsible for the remaining 7% of the variance. The analysis also provided standardized factor scoring coefficients for use in subsequent studies using similar experimental techniques.
本研究的目的是描述正常马的潮气呼吸流量-容积环（TBFVL）特征。该研究使用了18匹健康的纯种马进行。从静息马匹收集的数据构建的TBFVL具有典型的双相吸气和呼气阶段。用于描述TBFVL的指标的个体间变异性在16%至32%的范围内，这与马肺力学其他测量指标的变异性相当。这些数据的较大变异性可能限制了静息TBFVL指标在检测个体马匹亚临床呼吸状况方面的价值。对这些数据的因子分析表明，超过90%的初始反应变量的方差可以用三个共同因子来解释。对这三个共同因子进行方差最大化旋转后得到三个后续因子，它们很容易被识别为：（1）一个描述TBFVL时间-容积关系的因子，占总方差的81%；（2）一个解释TBFVL呼气部分的因子，解释方差的12%；（3）一个描述环的吸气部分的因子，占剩余方差的7%。该分析还提供了标准化因子得分系数，供后续使用类似实验技术的研究使用。
