Check J H, Nazari A, Dietterich C
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, USA.
Gynecol Endocrinol. 1995 Sep;9(3):209-14. doi: 10.3109/09513599509160448.
Serum concentrations of androstenedione, testosterone and dehypdroepiandrosterone sulfate (DHEAS) as well as estradiol and progesterone were measured throughout the in vitro fertilization (IVF) cycle and compared by conception outcome to try to determine if differing levels of androgens could help elucidate the endocrine environment conducive to successful IVF cycles. The luteal phase gonadotropin-releasing hormone agonist (GnRH-a) protocol was used for ovarian stimulation. of the 46 women enrolled in the study, 11 conceived and 35 did not conceive. Throughout the follicular phase, levels of androstenedione and DHEAS were found to rise but the same pattern of increase was found in both conception and non-conception cycles. The pattern of testosterone increase in non-conception cycles was faster than that in conception cycles. Differences in mean levels of androstenedione, testosterone, estradiol and progesterone by conception outcome in the late luteal phase can be attributed to secretion by the corpus luteum. It is possible that those women having multiple failed cycles with rapidly rising serum testosterone levels should be considered for longer use of the GnRH-a. Differences in the pattern of testosterone rise should be monitored.
在整个体外受精（IVF）周期中测量血清雄烯二酮、睾酮、硫酸脱氢表雄酮（DHEAS）以及雌二醇和孕酮的浓度，并根据受孕结果进行比较，以试图确定不同水平的雄激素是否有助于阐明有利于成功IVF周期的内分泌环境。黄体期促性腺激素释放激素激动剂（GnRH-a）方案用于卵巢刺激。在参与该研究的46名女性中，11人受孕，35人未受孕。在整个卵泡期，发现雄烯二酮和DHEAS水平升高，但在受孕和未受孕周期中均发现相同的升高模式。未受孕周期中睾酮升高的模式比受孕周期更快。黄体晚期根据受孕结果，雄烯二酮、睾酮、雌二醇和孕酮的平均水平差异可归因于黄体的分泌。对于那些血清睾酮水平迅速上升但多次周期失败的女性，可能应考虑延长GnRH-a的使用时间。应监测睾酮升高模式的差异。
