培养的心脏细胞中腺苷受体的调节
Regulation of adenosine receptors in cultured heart cells.
作者信息
el-Ani D, Jacobson K A, Shainberg A
机构信息
Otto Meyerhoff Drug Receptor Center, Department of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
出版信息
Adv Exp Med Biol. 1995;382:205-15. doi: 10.1007/978-1-4615-1893-8_21.
Abstract
A1 adenosine receptors were studied on heart cells grown in cultures by the radioligand binding technique. Treatments with agents that accelerated heart rate for 3-4 days, caused an increase in the level of adenosine receptors. Treatments that attenuated heart rate, reduced the level of the receptors. Thus, the cardiac cells respond to environmental conditions affecting heart contraction so as to restore the basal rate of heart activity.
摘要
采用放射性配体结合技术，对培养的心脏细胞上的A1腺苷受体进行了研究。用能使心率加快3 - 4天的药物进行处理，会导致腺苷受体水平升高。而使心率减慢的处理则会降低受体水平。因此，心脏细胞会对影响心脏收缩的环境条件做出反应，以恢复心脏活动的基础速率。
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本文引用的文献
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