急性髓系白血病中[6;9;8](p23;q34;q22)易位：荧光原位杂交的作用
[Translocation t(6;9;8)(p23;q34;q22) in acute myeloid leukemia: Contribution of fluorescence in situ hybridization].
作者信息
van den Akker J, Pérot C, Portnoï M F, Philizot L, Dupont J M, Laporte J P, Taillemite J L
机构信息
Laboratoire de Cytogénétique, Hôpital Saint-Antoine, Paris, France.
出版信息
Ann Genet. 1995;38(3):168-71.
A complex translocation involving chromosome 6, 8 and 9 [t(6;9;8)(p23;q34;q22)] associated with other structural and numerical abnormalities was observed on bone marrow karyotype of a woman suffering with acute myeloblastic leukemia (AML2). Fluorescence in situ hybridization agreed with the conventional cytogenetic interpretation by showing that a part of chromosome 6 short arm was inserted on the rearranged chromosome 9 resulting in the t (6;9) usually encountered in AML.
在一名患有急性髓细胞白血病（AML2）的女性患者的骨髓核型中，观察到涉及6号、8号和9号染色体的复杂易位[t(6;9;8)(p23;q34;q22)]，并伴有其他结构和数目异常。荧光原位杂交结果与传统细胞遗传学解释一致，显示6号染色体短臂的一部分插入到重排的9号染色体上，导致AML中常见的t(6;9)。
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