Iven H, Brasch H
Naunyn Schmiedebergs Arch Pharmacol. 1977 Mar;297(2):153-61. doi: 10.1007/BF00499925.
Lidocaine (3-10(-5) and 10(-4) M) and equimolar concentrations of brufacain dose-dependently reduced the depolarization velocity (dV/dtmax) and the force of contraction of guinea pig atria and papillary muscles. Repolarization time was increased in atria but reduced in papillary muscles. The maximum effects on action potential parameters were identical but developed with brufacain more slowly than with lidocaine. In papillary muscles lidocaine (3-10(-5) M) prolonged the functional refractory period. No such effect but even a shortening was observed with brufacain. As brufacain reduced the duration of the action potential (AP) more than the functional refractory period, the "relative refractory period" (in percent of AP duration) was slightly prolonged. The half-time of the recovery of the Na+ system was increased three to five times the control value after lidocaine but only doubled after brufacain.
利多卡因（3×10⁻⁵和10⁻⁴M）以及等摩尔浓度的布法卡因剂量依赖性地降低豚鼠心房和乳头肌的去极化速度（dV/dtmax）和收缩力。心房的复极化时间延长，而乳头肌的复极化时间缩短。对动作电位参数的最大影响相同，但布法卡因的作用比利多卡因发展得更慢。在乳头肌中，利多卡因（3×10⁻⁵M）延长了功能不应期。布法卡因未观察到这种作用，甚至观察到缩短。由于布法卡因比功能不应期更能缩短动作电位（AP）的持续时间，“相对不应期”（占AP持续时间的百分比）略有延长。利多卡因作用后，Na⁺系统恢复的半衰期增加到对照值的三到五倍，但布法卡因作用后仅增加一倍。
