慢性进行性外眼肌麻痹患者皂素透皮骨骼肌纤维线粒体功能的激光激发荧光研究
Laser-excited fluorescence studies of mitochondrial function in saponin-skinned skeletal muscle fibers of patients with chronic progressive external ophthalmoplegia.
作者信息
Winkler K, Kuznetsov A V, Lins H, Kirches E, von Bossanyi P, Dietzmann K, Frank B, Feistner H, Kunz W S
机构信息
Klinik für Neurologie, Universitätsklinikum Magdeburg, Germany.
出版信息
Biochim Biophys Acta. 1995 Dec 12;1272(3):181-4. doi: 10.1016/0925-4439(95)00085-2.
PMID:8541350
Abstract
The functional behavior of mitochondria in skeletal muscle of patients with chronic progressive external ophthalmoplegia was studied by laser-excited fluorescence measurements of NAD(P)H and flavoproteins in saponin-skinned fibers. Variations in the mitochondrial content and the presence of partially respiratory chain-inhibited mitochondria can be detected using this novel method.
摘要
通过对皂素透皮纤维中NAD(P)H和黄素蛋白进行激光激发荧光测量，研究了慢性进行性外眼肌麻痹患者骨骼肌中线粒体的功能行为。使用这种新方法可以检测线粒体含量的变化以及部分呼吸链受抑制的线粒体的存在。
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