Wang Haiwei, Fang Bin, Peng Bo, Wang Limin, Xue Yufei, Bai Hua, Lu Shenci, Voelcker Nicolas H, Li Lin, Fu Li, Huang Wei
Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, Xi'an, China.
School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an, China.
Front Chem. 2021 May 3;9:683220. doi: 10.3389/fchem.2021.683220. eCollection 2021.
Mitochondria are vital subcellular organelles that generate most cellular chemical energy, regulate cell metabolism and maintain cell function. Mitochondrial dysfunction is directly linked to numerous diseases including neurodegenerative disorders, diabetes, thyroid squamous disease, cancer and septicemia. Thus, the design of specific mitochondria-targeting molecules and the realization of real-time acquisition of mitochondrial activity are powerful tools in the study and treatment of mitochondria dysfunction in related diseases. Recent advances in mitochondria-targeting agents have led to several important mitochondria chemical probes that offer the opportunity for selective targeting molecules, novel biological applications and therapeutic strategies. This review details the structural and physiological functional characteristics of mitochondria, and comprehensively summarizes and classifies mitochondria-targeting agents. In addition, their pros and cons and their related chemical biological applications are discussed. Finally, the potential biomedical applications of these agents are briefly prospected.
线粒体是至关重要的亚细胞器，可产生大部分细胞化学能量、调节细胞代谢并维持细胞功能。线粒体功能障碍与多种疾病直接相关，包括神经退行性疾病、糖尿病、甲状腺鳞状疾病、癌症和败血症。因此，设计特定的线粒体靶向分子并实现线粒体活性的实时获取，是研究和治疗相关疾病中线粒体功能障碍的有力工具。线粒体靶向剂的最新进展已产生了几种重要的线粒体化学探针，为选择性靶向分子、新型生物学应用和治疗策略提供了机会。本文综述详细介绍了线粒体的结构和生理功能特征，并对线粒体靶向剂进行了全面的总结和分类。此外，还讨论了它们的优缺点及其相关的化学生物学应用。最后，简要展望了这些试剂潜在的生物医学应用。
