Bronner-Fraser M
Developmental Biology Center, University of California, Irvine 92717, USA.
Perspect Dev Neurobiol. 1995;3(1):53-62.
The mechanisms underlying neural crest cell migration are beginning to be understood thanks to the ability to combine a number of techniques in experimental embryology, cell and molecular biology. In the trunk, cell-cell interactions may predominate, so that the mesodermal somites control the rostrocaudal patterning of neural crest cells and the notochord prevents neural crest cells from crossing the midline. In the hindbrain, the segmental migration of neural crest cells may be influenced both by information inherent to the rhombomeres coupled with environmental signals from neighboring tissues, such as the otic vesicle. There is clearly an intimate relationship between migrating neural crest cells, the neural tube from which they emerge, and tissues through which they move. All of these elements are integral in the control of neural crest migration.
由于能够将实验胚胎学、细胞和分子生物学中的多种技术结合起来，神经嵴细胞迁移的潜在机制正开始被人们所理解。在躯干中，细胞间相互作用可能占主导地位，中胚层体节控制神经嵴细胞的头尾模式，而脊索则阻止神经嵴细胞越过中线。在后脑中，神经嵴细胞的节段性迁移可能受到菱脑节固有信息以及来自邻近组织（如耳泡）的环境信号的双重影响。迁移的神经嵴细胞、它们所起源的神经管以及它们移动所经过的组织之间显然存在着密切的关系。所有这些因素在神经嵴迁移的控制中都是不可或缺的。
