Popova T G, Asocakiĭ M G
Genetika. 1995 Oct;31(10):1365-9.
This paper is devoted to an analysis of the intrinsic structure of the gene from the point of view of the redundancy of different structural units--exons and introns. Human genes for which the exon-intron structure has been clearly established were studied. The redundancy of each exon and intron in the gene was determined. It was shown that, in human genes, introns are more redundant than exons. Redundancy is determined as the smallest length of a word (oligonucleotide) beginning with which all words in the studied nucleotide sequence are found exactly once. Mechanisms leading to the disruption of the general pattern of ratios of redundancy of exons and introns are studied.
本文致力于从不同结构单元——外显子和内含子的冗余性角度分析基因的内在结构。研究了外显子 - 内含子结构已明确确定的人类基因。确定了基因中每个外显子和内含子的冗余性。结果表明,在人类基因中,内含子比外显子更具冗余性。冗余性被确定为一个单词(寡核苷酸)的最小长度,从该长度开始,所研究核苷酸序列中的所有单词都恰好出现一次。研究了导致外显子和内含子冗余比例总体模式被破坏的机制。