Moshkovitz Y, Lusky A, Mor R
Dept. of Cardiac Surgery, Chaim Sheba Medical Center, Tel Hashomer.
Harefuah. 1995 Aug;129(3-4):81-7, 160.
240 patients underwent coronary artery bypass grafting (CABG) without extracorporeal circulation (ECC). Mean grafts per patient was 1.9 (range 1-5). The internal mammary artery (IMA) was used in 210 cases (87%), but in only 53 (22%) were there grafts to the circumflex marginals. Unfavorable results included an operative mortality of 7 cases (2.9%), nonfatal perioperative myocardial infarction (MI) (2.5%), stroke (0.4%), and sternal infection (1.7%). There were 2 deaths among 17 patients (12%) with calcified aorta, and 4 among 40 (10%) who underwent emergency operation. Multivariate analysis showed these 2 risk factors to be the only predictors of early mortality: emergency operation odds ratio 9.8, and calcified aorta odds ratio 8.0. Perioperative risk factors that were not major predictors of early mortality or unfavorable outcome included left ventricular dysfunction (EF < 35%: 52 patients, 22%), congestive heart failure (53, 22%), cardiogenic shock (8, 3%), acute MI (67, 28%), age > 70 years (64, 27%), renal failure (22, 9%), and stroke or carotid disease (12, 5%). Followup ranged from 1-31 months (mean 12). There were 9 late deaths (4 cardiac), and 18 cases (7.5%) of early return of angina. 1-year actuarial survival was 92%; 192 patients (80%) had uneventful outcomes and are doing well. Calcified aorta, nonuse of the IMA, reoperation, and diabetes mellitus were independent predictors of unfavorable events. We conclude that CABG without ECC can be performed with relatively low operative mortality, but there seems to be increased risk of early return of angina. It should therefore be considered for those patients with appropriate coronary anatomy in whom ECC poses a very high risk. However, it is still a hazardous procedure when used as as an emergency operation, and for cases with calcified aorta.
240例患者接受了非体外循环冠状动脉旁路移植术(CABG)。每位患者平均移植血管数为1.9根(范围1 - 5根)。210例(87%)使用了乳内动脉(IMA),但仅有53例(22%)移植血管至回旋支边缘支。不良结果包括7例(2.9%)手术死亡、非致命性围手术期心肌梗死(MI)(2.5%)、中风(0.4%)和胸骨感染(1.7%)。17例(12%)主动脉钙化患者中有2例死亡,40例(10%)接受急诊手术的患者中有4例死亡。多因素分析显示这两个危险因素是早期死亡的唯一预测因素:急诊手术比值比9.8,主动脉钙化比值比8.0。并非早期死亡或不良结局主要预测因素的围手术期危险因素包括左心室功能障碍(射血分数<35%:52例患者,22%)、充血性心力衰竭(53例,22%)、心源性休克(8例,3%)、急性心肌梗死(67例,28%)、年龄>70岁(64例,27%)、肾衰竭(22例,9%)以及中风或颈动脉疾病(12例,5%)。随访时间为1 - 31个月(平均12个月)。有9例晚期死亡(4例心脏相关),18例(7.5%)早期心绞痛复发。1年预期生存率为92%;192例(80%)患者预后良好。主动脉钙化、未使用IMA、再次手术和糖尿病是不良事件的独立预测因素。我们得出结论,非体外循环CABG手术死亡率相对较低,但早期心绞痛复发风险似乎增加。因此,对于体外循环风险极高且冠状动脉解剖结构合适的患者可考虑采用。然而,作为急诊手术以及用于主动脉钙化病例时,它仍然是一种危险的手术。