Gupta S, Ghosh P K, Dutta G P, Vishwakarma R A
Central Drug Research Institute, Lucknow, India.
J Parasitol. 1995 Dec;81(6):1012-3.
Artemisinin and its derivatives, beta-arteether and sodium artesunic acid, have been evaluated for activity against experimental primary amebic meningoencephalitis and the efficacy of these compounds has been compared with that of the standard drug amphotericin B. In vivo experiments in Swiss mice have shown that amphotericin B at a dose of 2.5 mg/kg for 5 days produced 100% protection in the mice infected intranasally with Naegleria fowleri. Artemisinin, beta-arteether, and sodium artesunic acid, even when tested at high doses (60-180 mg/kg x 5 days), were not curative and showed only slight protection as indicated by extension of mean survival time.
青蒿素及其衍生物，如蒿甲醚和青蒿琥酯钠，已针对实验性原发性阿米巴脑膜脑炎的活性进行了评估，并将这些化合物的疗效与标准药物两性霉素B进行了比较。在瑞士小鼠身上进行的体内实验表明，以2.5毫克/千克的剂量连续给药5天的两性霉素B，对经鼻感染福氏耐格里阿米巴的小鼠产生了100%的保护作用。青蒿素、蒿甲醚和青蒿琥酯钠，即使在高剂量（60 - 180毫克/千克×5天）下进行测试，也没有治愈效果，仅表现出轻微的保护作用，如平均存活时间延长所示。
