Taniguchi T, Matsumoto Y, Yoneda T, Mori I, Kobayashi H, Yamamoto K
Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University.
Masui. 1995 Nov;44(11):1467-71.
We studied the changes in plasma cytokine (IL-6 and IL-8) levels during lung surgery in 20 patients. The correlation between the changes in cytokine levels and surgical stress as well as the postoperative complications were examined. The levels of IL-6 and IL-8 increased shortly after the surgical incision and were 326 pg.ml-1 and 61 pg.ml-1 respectively, at the end of surgery. The changes in cytokine levels correlated well with the duration of surgery, blood loss and CPR levels for 2 days after the surgery. However, there were no severe postoperative complications in the present study. We conclude that the cytokines increase shortly after the surgical incision and the changes in cytokine levels correlate well with the surgical stress.
我们研究了20例患者肺部手术期间血浆细胞因子（IL-6和IL-8）水平的变化。检测了细胞因子水平变化与手术应激以及术后并发症之间的相关性。手术切口后不久，IL-6和IL-8水平升高，手术结束时分别为326 pg.ml-1和61 pg.ml-1。细胞因子水平的变化与手术持续时间、失血量以及术后2天的CPR水平密切相关。然而，本研究中未出现严重的术后并发症。我们得出结论，手术切口后不久细胞因子增加，且细胞因子水平的变化与手术应激密切相关。
