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[起源于唾液腺黏膜相关淋巴组织且经尸检诊断的肺非霍奇金淋巴瘤]

[Pulmonary non-Hodgkin's lymphoma that arose in mucosa-associated lymphoid tissue of the salivary gland and was diagnosed at autopsy].

作者信息

Kita T, Fujimura M, Hayase M, Matsuda T, Nonomura A

机构信息

Department of Internal Medicine, Johana Kousei Hospital, Toyoma, Japan.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Oct;33(10):1119-24.

PMID:8544385
Abstract

A 70-year-old woman complained of a dry mouth and swelling in the area of the left parotid gland for 6 years, and was admitted for evaluation of an abnormal shadow on chest X-ray film. She underwent a lip biopsy and a 99mTcO4- scintigram of the salivary gland, and Sjögren's syndrome was diagnosed. Histopathological examination of the percutaneous lung biopsy specimen showed pseudolymphoma, and examination of a specimen of the left parotid gland tumor showed myoepithelial sialadenitis. The patient died of respiratory failure due to a right pleural effusion 4 years later. Autopsy revealed pulmonary non-Hodgkin's lymphoma (diffuse, large, B cell, IgG) with monotonous infiltration of centrocyte-like cells. A retrospectively resected specimen of the left parotid gland tumor showed non-Hodgkin's lymphoma similar to that found in the autopsied lung. This patient probably had pulmonary non-Hodgkin's lymphoma that arose in mucosa-associated lymphoid tissue of the salivary gland and was associated with Sjögren's syndrome.

摘要

一名70岁女性主诉口干及左腮腺区肿胀6年,因胸部X线片出现异常阴影入院评估。她接受了唇部活检及唾液腺99mTcO4-闪烁扫描,诊断为干燥综合征。经皮肺活检标本的组织病理学检查显示为假性淋巴瘤,左腮腺肿瘤标本检查显示为肌上皮涎腺炎。4年后,患者因右侧胸腔积液死于呼吸衰竭。尸检发现肺部非霍奇金淋巴瘤(弥漫性、大细胞、B细胞、IgG型),有中心细胞样细胞的单一浸润。回顾性切除的左腮腺肿瘤标本显示出与尸检肺部发现的相似的非霍奇金淋巴瘤。该患者可能患有起源于唾液腺黏膜相关淋巴组织且与干燥综合征相关的肺部非霍奇金淋巴瘤。

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