Veglio F, Frascisco M, Melchio R, Provera E, Rabbia F, Oliva S, Chiandussi L
Department of Medicine and Experimental Oncology, University Turin, Italy.
Kidney Int. 1995 Nov;48(5):1611-6. doi: 10.1038/ki.1995.455.
Ultrasonic duplex scanning has been validated as a noninvasive method to evaluate the kidney arteries and hemodynamic characteristics of renal blood flow in patients with renal artery stenosis. The purpose of our study was to assess the changes in renal vascular impedance in 22 patients with renovascular hypertension, as compared with 45 essential hypertensives and 15 normotensives, by using the Doppler parameter resistance index (RI) before and after a captopril oral test. After the captopril test the delta RI decreased significantly in the stenotic artery (P < 0.05). Univariate analysis showed that PRA values after captopril correlated inversely with the changes of RI only in the stenotic artery (P < 0.05). Thus, our findings suggest that the application of the captopril test to renal echo-Doppler may represent a feasible, noninvasive, and inexpensively useful tool in the screening studies aimed at diagnosing renovascular hypertension.
超声双功扫描已被确认为一种无创方法，用于评估肾动脉狭窄患者的肾动脉及肾血流的血流动力学特征。我们研究的目的是，通过口服卡托普利前后使用多普勒参数阻力指数（RI），评估22例肾血管性高血压患者与45例原发性高血压患者及15例血压正常者相比肾血管阻抗的变化。卡托普利试验后，狭窄动脉的RI变化值显著降低（P<0.05）。单因素分析显示，仅在狭窄动脉中，卡托普利后的血浆肾素活性（PRA）值与RI变化呈负相关（P<0.05）。因此，我们的研究结果表明，将卡托普利试验应用于肾脏回声多普勒检查，可能是一种可行、无创且成本低廉的有用工具，可用于旨在诊断肾血管性高血压的筛查研究。
