Singh G, Singh D P, Gupta D, Muralikrishna B V
Department of Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Surg Oncol. 1996 Jan;61(1):38-41. doi: 10.1002/(SICI)1096-9098(199601)61:1<38::AID-JSO9>3.0.CO;2-T.
Thirty-eight patients with locally advanced breast cancer (Stage III) were treated over a 3-year period. All patients initially received two cycles of CMF (cyclophosphamide, 100 mg/m2 p.o. d1-14; methotrexate 40 mg/m2 intravenously (i.v.), d1 and d8., 5 Fluorouracil 500 mg/m2 i.v. d1 and d8). They were then subjected to surgery and external beam irradiation to the chest field and drainage areas. Four more cycles of chemotherapy completed the treatment protocol. A response to initial chemotherapy was seen in 75.7% patients, with two patients achieving a complete response. No patient had disease progression while on chemotherapy. Tumor reduction of a degree to allow breast conservation procedures was seen in eight patients. The chemotherapy was well tolerated. Twelve patients failed to complete the treatment protocol. Follow-up for the remaining 26 ranges from 9-40 months (mean 18 months). Ten patients developed a recurrence. Of those, only one had isolated local recurrence, two had local and systemic recurrence, and seven had systemic disease alone. Patients with recurrence were salvaged with further chemotherapy (Adriamycin and cyclophosphamide).
38例局部晚期乳腺癌（Ⅲ期）患者在3年期间接受了治疗。所有患者最初接受两个周期的CMF方案（环磷酰胺，口服100mg/m²，第1 - 14天；甲氨蝶呤40mg/m²静脉注射，第1天和第8天；5-氟尿嘧啶500mg/m²静脉注射，第1天和第8天）。然后他们接受手术，并对胸部区域和引流区域进行外照射。另外四个周期的化疗完成了治疗方案。75.7%的患者对初始化疗有反应，两名患者达到完全缓解。化疗期间无患者疾病进展。8例患者肿瘤缩小到允许保乳手术的程度。化疗耐受性良好。12例患者未能完成治疗方案。其余26例患者的随访时间为9 - 40个月（平均18个月）。10例患者出现复发。其中，仅1例为孤立性局部复发，2例为局部和全身复发，7例仅为全身性疾病。复发患者通过进一步化疗（阿霉素和环磷酰胺）进行挽救治疗。
