McCarthy P V, Bhatia A J, Saw S M, Mosley J D, Vega-Quiñones A
Master of Public Health Program, Johns Hopkins University School of Hygiene and Public Health, USA.
Md Med J. 1995 Dec;44(12):1039-42.
To investigate the frequency of cigarette smoking in patients who have been diagnosed with bladder cancer, data were obtained for 1507 subjects listed in the 1975 private census of Washington County, Maryland. Case subjects were defined as persons at least 18 years of age diagnosed with bladder cancer (ICD code = 188.0 to 188.9) between 1975 and 1992 for whom smoking information was available. Control subjects were defined as a random sample of persons frequency matched by age and sex to the cases. Controls were free of bladder cancer and had smoking information available. The odds ratio for current smokers for the association between smoking and bladder cancer adjusted for age and sex was statistically significant (OR = 1.68, 95% confidence intervals, 1.22 to 2.32). The chi-square trend test of the dose-response results was significant (chi-square = 11.69, df = 1, P < .01).
为调查已确诊膀胱癌患者的吸烟频率，我们获取了马里兰州华盛顿县1975年私人人口普查列出的1507名受试者的数据。病例受试者定义为1975年至1992年间至少18岁、被诊断患有膀胱癌（国际疾病分类代码=188.0至188.9）且有吸烟信息的人。对照受试者定义为按年龄和性别与病例进行频率匹配的随机抽样人群。对照者无膀胱癌且有吸烟信息。经年龄和性别调整后，当前吸烟者吸烟与膀胱癌关联的优势比具有统计学意义（优势比=1.68，95%置信区间为1.22至2.32）。剂量反应结果的卡方趋势检验具有显著性（卡方=11.69，自由度=1，P<0.01）。
