Piette J, Defechereux P, Baudoux L, Debrus S, Merville M P, Rentier B
Department of Microbiology, University of Liège, Belgium.
Neurology. 1995 Dec;45(12 Suppl 8):S23-7. doi: 10.1212/wnl.45.12_suppl_8.s23.
The varicella-zoster virus genome contains 71 open reading frames (ORFs), five of which (ORF62, ORF4, ORF63, ORF61, and ORF10) encode regulatory proteins. ORF62 codes for the major immediate early protein of the virus exhibiting DNA-binding and regulatory functions. This protein, localized in the cell nucleus, is a functional homologue to ICP4 of herpes simplex virus type 1 (HSV-1). It trans-activates several varicella-zoster virus promoters of the various gene classes and autoregulates its own expression. ORF4 protein activates gene promoters provided they have basal activities, but it is not a functional homologue of HSV-1 ICP27. Gene regulation activity appears to be linked to its cysteine-rich C-terminal region. ORF63 codes for an immediate early protein mainly located in the cell nucleus. The regulatory functions it performs are still unclear. ORF61 protein is the functional homologue of HSV-1 ICP0. Its N-terminal region exhibits a RING domain responsible for trans-activating and trans-repressing activities. ORF10 protein exhibits similarities with HSV-1 VP16 and activates the ORF62 promoter.
水痘带状疱疹病毒基因组包含71个开放阅读框（ORF），其中五个（ORF62、ORF4、ORF63、ORF61和ORF10）编码调节蛋白。ORF62编码病毒的主要立即早期蛋白，具有DNA结合和调节功能。这种蛋白定位于细胞核，是1型单纯疱疹病毒（HSV-1）的ICP4的功能同源物。它反式激活各种基因类别的几个水痘带状疱疹病毒启动子，并自我调节其自身表达。ORF4蛋白激活具有基础活性的基因启动子，但它不是HSV-1 ICP27的功能同源物。基因调节活性似乎与其富含半胱氨酸的C末端区域有关。ORF63编码一种主要位于细胞核的立即早期蛋白。其执行的调节功能仍不清楚。ORF61蛋白是HSV-1 ICP0的功能同源物。其N末端区域具有负责反式激活和反式抑制活性的RING结构域。ORF10蛋白与HSV-1 VP16具有相似性，并激活ORF62启动子。
