水痘带状疱疹病毒刺激的淋巴细胞培养物中的细胞因子产生
Cytokine production in varicella-zoster virus-stimulated lymphocyte cultures.
作者信息
Zhang Y, White C J, Levin M, Hayward A
机构信息
Department of Pediatrics, University of Colorado School of Medicine, Denver 80262, USA.
出版信息
Neurology. 1995 Dec;45(12 Suppl 8):S38-40. doi: 10.1212/wnl.45.12_suppl_8.s38.
Among varicella-zoster virus (VZV)-immune adults aged 20 to 35 years, T lymphocytes producing interferon-gamma (IFN-gamma) in response to a VZV antigen stimulus are eight times more numerous than those making interleukin-4 (IL-4). In persons over 55 years old, the frequency of IFN-gamma-making cells falls while the number of IL-4-making cells remains roughly constant. The persistence of IL-4-making cells may contribute to the maintenance of IgG antibodies to VZV with aging.
在20至35岁对水痘带状疱疹病毒（VZV）免疫的成年人中，因VZV抗原刺激而产生γ干扰素（IFN-γ）的T淋巴细胞数量是产生白细胞介素-4（IL-4）的T淋巴细胞数量的八倍。在55岁以上的人群中，产生IFN-γ的细胞频率下降，而产生IL-4的细胞数量大致保持不变。随着年龄增长，产生IL-4的细胞持续存在可能有助于维持针对VZV的IgG抗体。
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