降钙素基因相关肽拮抗剂可增强幽门结扎2小时大鼠的胃酸分泌。

CGRP antagonists enhance gastric acid secretion in 2-h pylorus-ligated rats.

作者信息

Kato K, Martinez V, St Pierre S, Taché Y

机构信息

CURE/UCLA Gastroenteric Biology Center, VA Wadsworth Medical Center 90073, USA.

出版信息

Peptides. 1995;16(7):1257-62. doi: 10.1016/0196-9781(95)02004-g.

DOI:10.1016/0196-9781(95)02004-g

PMID:8545247

Abstract

The influence of calcitonin gene-related peptide (CGRP) antagonists on gastric acid secretion was investigated in rats. Intravenous injection of the CGRP receptor antagonist, CGRP(8-37) (128 nmol/kg) or the CGRP antibody #4901 (4.8 mg/kg, IV) completely prevented alpha-CGRP (3.9 nmol/kg/h)-induced inhibition of acid response to pentagastrin in urethane-anesthetized rats with gastric fistula. CGRP antibody (4.8 mg/kg, IV) increased by 93% gastric acid secretion in conscious rats with pylorus ligation for 2 h. (CGRP(8-73) (128 nmol/kg, IV) also enhanced the acid response measured 2 h after pylorus ligation in conscious rats and in urethane-anesthetized rats infused with pentagastrin by 91% and 56%, respectively. These results suggest that endogenous CGRP attenuates the gastric acid response measured 2 h after pylorus ligation.

摘要

在大鼠中研究了降钙素基因相关肽（CGRP）拮抗剂对胃酸分泌的影响。静脉注射CGRP受体拮抗剂CGRP（8 - 37）（128 nmol/kg）或CGRP抗体#4901（4.8 mg/kg，静脉注射）可完全阻止α-CGRP（3.9 nmol/kg/h）对幽门结扎2小时的有意识大鼠和用胃瘘的氨基甲酸乙酯麻醉大鼠中五肽胃泌素诱导的酸反应的抑制。CGRP抗体（4.8 mg/kg，静脉注射）使幽门结扎2小时的有意识大鼠的胃酸分泌增加了93%。（CGRP（8 - 73）（128 nmol/kg，静脉注射）在幽门结扎2小时的有意识大鼠和用五肽胃泌素灌注的氨基甲酸乙酯麻醉大鼠中，分别使酸反应增强了91%和56%。这些结果表明，内源性CGRP减弱了幽门结扎2小时后测得的胃酸反应。