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再生障碍性贫血后成功妊娠。

Successful pregnancy following aplastic anaemia.

作者信息

Leong K W, Teh A, Bosco J J, Lim J

机构信息

Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

出版信息

Postgrad Med J. 1995 Oct;71(840):625-7. doi: 10.1136/pgmj.71.840.625.

DOI:10.1136/pgmj.71.840.625
PMID:8545293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2398268/
Abstract

Pregnancy following idiopathic aplastic anaemia is rare and is difficult to manage because of life-threatening episodes of bleeding and infections. Only a handful of cases has been reported in the literature. The pregnancies were unsuccessful in the majority. The present report describes a patient with moderately severe idiopathic aplastic anaemia who was managed with intensive haematological support leading to delivery of a healthy infant by caesarean section. Despite platelet transfusion refractoriness as a result of transfusions prior to pregnancy, adequate platelet transfusions prevented excessive bleeding. The literature is reviewed and management with platelet transfusions is discussed.

摘要

特发性再生障碍性贫血后妊娠较为罕见,且由于存在危及生命的出血和感染发作,管理起来颇具难度。文献中仅报道了少数病例。大多数妊娠均未成功。本报告描述了一名患有中度严重特发性再生障碍性贫血的患者,该患者在强化血液学支持下接受治疗,最终通过剖宫产分娩出一名健康婴儿。尽管由于妊娠前输血导致血小板输注无效,但充足的血小板输注预防了过度出血。本文对相关文献进行了综述,并讨论了血小板输注的管理。

相似文献

1
Successful pregnancy following aplastic anaemia.再生障碍性贫血后成功妊娠。
Postgrad Med J. 1995 Oct;71(840):625-7. doi: 10.1136/pgmj.71.840.625.
2
A case of aplastic anaemia in pregnancy.一例妊娠期再生障碍性贫血病例。
Aust N Z J Obstet Gynaecol. 1999 Feb;39(1):102-5. doi: 10.1111/j.1479-828x.1999.tb03455.x.
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Management of aplastic anaemia in pregnancy in a resource poor centre.资源匮乏地区中心妊娠期再生障碍性贫血的管理
Pan Afr Med J. 2016 Jul 28;24:277. doi: 10.11604/pamj.2016.24.277.9880. eCollection 2016.
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Perioperative management of aplastic anemia in pregnancy with platelet transfusion refractoriness.妊娠合并血小板输注无效的再生障碍性贫血的围手术期管理
Can J Anaesth. 2007 Oct;54(10):851. doi: 10.1007/BF03021717.
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Severe aplastic anaemia relapsing during a pregnancy; spontaneous remission following termination.重度再生障碍性贫血在孕期复发;终止妊娠后自发缓解。
Haematologia (Budap). 1998;29(2):147-51.
6
[Therapeutic problems during pregnancy and delivery in two women with aplastic anemia].[两名再生障碍性贫血女性妊娠及分娩期间的治疗问题]
Acta Haematol Pol. 1993;24(2):183-9.
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[Aplastic anaemia associated with pregnancy].[妊娠相关性再生障碍性贫血]
Akush Ginekol (Sofiia). 2012;51(4):50-3.
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Pregnancy associated aplastic anaemia: a report of five cases and review of current management.妊娠相关性再生障碍性贫血:5例报告及当前治疗方法综述
Br J Haematol. 1989 Dec;73(4):541-5. doi: 10.1111/j.1365-2141.1989.tb00294.x.
9
Successful management of pregnancy-associated severe aplastic anemia.妊娠相关性重型再生障碍性贫血的成功管理
Eur J Obstet Gynecol Reprod Biol. 2007 Apr;131(2):244-5. doi: 10.1016/j.ejogrb.2006.04.040. Epub 2006 Jun 19.
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Successful outcome of pregnancy in a case of aplastic anaemia in Jordan.约旦一名再生障碍性贫血患者成功妊娠结局。
East Mediterr Health J. 2004 May;10(3):445-8.

引用本文的文献

1
Aplastic anaemia in pregnancy with severe thrombocytopenia refractory to platelet transfusion: a case and management plan.妊娠合并再生障碍性贫血伴严重血小板减少且对血小板输注难治:1例病例及处理方案
Obstet Med. 2009 Mar;2(1):26-9. doi: 10.1258/om.2008.080035. Epub 2009 Mar 1.
2
Association of severe thrombocytopenia and poor prognosis in pregnancies with aplastic anemia.再生障碍性贫血妊娠中严重血小板减少与不良预后的关联。
PLoS One. 2014 Jul 24;9(7):e103066. doi: 10.1371/journal.pone.0103066. eCollection 2014.

本文引用的文献

1
Aplastic anemia (first of two parts): pathogenesis, diagnosis, treatment, and prognosis.再生障碍性贫血(两部分中的第一部分):发病机制、诊断、治疗及预后
N Engl J Med. 1982 Mar 18;306(11):645-52. doi: 10.1056/NEJM198203183061105.
2
Bone marrow transplantation (BMT) versus immunosuppression for the treatment of severe aplastic anaemia (SAA): a report of the EBMT SAA working party.骨髓移植(BMT)与免疫抑制治疗重型再生障碍性贫血(SAA):欧洲血液与骨髓移植协会(EBMT)SAA工作组报告
Br J Haematol. 1988 Oct;70(2):177-82. doi: 10.1111/j.1365-2141.1988.tb02460.x.
3
Pregnancy associated aplastic anaemia: a report of five cases and review of current management.妊娠相关性再生障碍性贫血:5例报告及当前治疗方法综述
Br J Haematol. 1989 Dec;73(4):541-5. doi: 10.1111/j.1365-2141.1989.tb00294.x.
4
Factors influencing the transfusion response to HLA-selected apheresis donor platelets in patients refractory to random platelet concentrates.影响随机血小板浓缩物难治性患者对HLA选择的单采供血者血小板输血反应的因素。
Br J Haematol. 1989 Nov;73(3):380-6. doi: 10.1111/j.1365-2141.1989.tb07757.x.
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Pregnancy in idiopathic aplastic anemia (report of 10 patients).
Eur J Obstet Gynecol Reprod Biol. 1992 Jun 16;45(1):19-25. doi: 10.1016/0028-2243(92)90189-6.
6
Prognostic aspects of aplastic anemia in pregnancy. Experience on six cases and review of the literature.
Blut. 1978 May 18;36(5):285-98. doi: 10.1007/BF01880679.