Deneys V, Van Lierde M, De Bruyère M
Laboratoire d'Immunohématologie, Cliniques Universitaires Saint-Luc, Bruxelles, Belgique.
Presse Med. 1995 Nov 18;24(35):1651-7.
In mammals, reproduction involves two potentially incompatible mechanisms: viviparity and development of a competent immune system. Thus the maternal and foetal organisms must respond by developing immunologic tolerance. The phenomenon does not involve total immunosuppression, but includes several highly precise processes initiated at conception. It is known that cell- and humour-mediated processes occur but their relative importance remains to be elucidated. Cytokines, especially those mediating T-helper2 cell response appear to play a predominant role in inducing immunologic tolerance to the foetal allograft. A better understanding of these mechanisms could have major implications in the diagnosis and treatment of repeated miscarriage and unexplained infertility.
在哺乳动物中，生殖涉及两种潜在不兼容的机制：胎生和发育出有功能的免疫系统。因此，母体和胎儿机体必须通过形成免疫耐受来应对。这种现象并不涉及完全免疫抑制，而是包括受孕时启动的几个高度精确的过程。已知细胞介导和体液介导的过程都会发生，但其相对重要性仍有待阐明。细胞因子，尤其是那些介导辅助性T2细胞反应的细胞因子，似乎在诱导对胎儿同种异体移植物的免疫耐受中起主要作用。更好地理解这些机制可能对反复流产和不明原因不孕症的诊断和治疗产生重大影响。
