Center of Excellence for Research, Transfer and High Education DENOTHE of the University of Florence, Florence, Italy.
J Reprod Immunol. 2010 May;85(1):71-5. doi: 10.1016/j.jri.2010.01.006. Epub 2010 Mar 23.
The conceptus is considered a semi-allograft because of the presence of paternal HLA-C molecules. These alloantigens can be processed by maternal antigen presenting cells, which present them to specific maternal CD4+ T cells. After activation, the maternal CD4+ T cells can become effector decidual CD4+ T cells, which are able to release various cytokines. Th1-type cytokines (IFNgamma) that promote allograft rejection may compromise pregnancy, whereas the Th2-type cytokines (IL-4, IL-10) that inhibit Th1 responses, promote allograft tolerance and therefore may improve fetal survival. A collaborative interaction between the decidual natural regulatory T cells, CD4+ CD25+ Foxp3 T cells and NKT cells in preventing fetal allograft rejection is suggested.
胚胎被认为是半同种异体移植物，因为存在父系 HLA-C 分子。这些同种抗原可以被母体抗原呈递细胞处理，然后呈递给特定的母体 CD4+T 细胞。在激活后，母体 CD4+T 细胞可以成为效应性蜕膜 CD4+T 细胞，能够释放各种细胞因子。促进同种异体排斥的 Th1 型细胞因子（IFNγ）可能会损害妊娠，而抑制 Th1 反应的 Th2 型细胞因子（IL-4、IL-10）促进同种异体耐受，从而可能提高胎儿存活率。有研究表明，蜕膜自然调节性 T 细胞、CD4+CD25+Foxp3T 细胞和 NKT 细胞之间的协同作用可以防止胎儿同种异体排斥。
