Grahn R E, Kalman B A, Brennan F X, Watkins L R, Maier S F
Department of Psychology, University of Colorado, Boulder 80309, USA.
Pharmacol Biochem Behav. 1995 Nov;52(3):565-70. doi: 10.1016/0091-3057(95)00141-i.
The present experiments examined the sensitivity of the elevated plus-maze to the effects of stressor controllability. Previous work had established that inescapable but not an equal amount of escapable electric tail shock reduced social interaction. The present experiments demonstrate that prior exposure to shock alters elevated plus-maze behavior, but that this effect is not sensitive to the escapability of the shock. These experiments include a replication of the usual pharmacologic effects of benzodiazepine ligands (2 mg/kg diazepam; 0.4 mg/kg methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate) to demonstrate the sensitivity of the elevated plus-maze procedures used. The results provide additional support for the idea that the social interaction and elevated plus-maze measures of "anxiety" are sensitive to different processes.
本实验研究了高架十字迷宫对应激源可控性效应的敏感性。先前的研究已经证实，不可逃避但等量的可逃避电尾休克不会减少社会互动。本实验表明，预先暴露于电击会改变高架十字迷宫行为，但这种效应对应激的可逃避性不敏感。这些实验重复了苯二氮䓬配体（2mg/kg地西泮；0.4mg/kg甲基6,7-二甲氧基-4-乙基-β-咔啉-3-羧酸）的常见药理作用，以证明所使用的高架十字迷宫程序的敏感性。结果为“焦虑”的社会互动和高架十字迷宫测量对不同过程敏感这一观点提供了额外支持。
