Menestrina F, Chilosi M, Scarpa A
Istituto di Anatomia Patologica, Universită di Verona, Policlinico Borgo Roma, Italy.
Semin Diagn Pathol. 1995 Aug;12(3):256-69.
After many years of frustrating discussion concerning the nature of Hodgkin's and Reed-Sternberg cells and their role in the pathogenesis of Hodgkin's disease, interesting new information has recently been gathered through the use of new technologies. In light of these studies, Hodgkin's disease emerges as a heterogeneous disorder in which some separate new entities may be elucidated, such as nodular lymphocyte predominance Hodgkin's disease and anaplastic large-cell CD30+ lymphoma. In this review, we focus on the morphologic, phenotypic, molecular, and clinical features that have served to partially clarify controversial issues.
在围绕霍奇金细胞和里德-斯腾伯格细胞的性质及其在霍奇金病发病机制中的作用进行了多年令人沮丧的讨论之后，最近通过使用新技术收集到了有趣的新信息。鉴于这些研究，霍奇金病呈现为一种异质性疾病，其中一些不同的新实体可能会被阐明，如结节性淋巴细胞为主型霍奇金病和间变性大细胞CD30+淋巴瘤。在这篇综述中，我们聚焦于那些有助于部分澄清争议问题的形态学、表型、分子和临床特征。
