Akagi T, Sakata Y, Takemori H, Kimura S, Kudoh I, Suzuki H, Fukushi M, Aisawa T, Ishiguro Y, Yoshiike M, Osanai S
1st Dept. Internal Medicine, Hirosaki University.
Gan To Kagaku Ryoho. 1996 Jan;23(1):103-6.
A 66-year-old man with a complaint of dysphagia was diagnosed as advanced esophageal cancer. Barium swallow examination of the esophagus showed a narrowing 10 cm in length at Ei (type 3), and biopsy specimen from the lesion on endoscopic examination revealed adenosquamous carcinoma. Multiple lymph node metastasis were detected by CT scan. He was treated with a combination of low dose 5-fluorouracil (5-FU) and low dose cisplatin (CDDP). The regimen consisted of 5-FU (300 mg/body/day continuous infusion) and CDDP (10 mg/body/day continuous infusion) for 3 weeks. After 2 courses of this regimen, his symptoms disappeared, and only mild irregularity of the esophageal wall remained on Barium swallow examination. The effect of the therapy was evaluated as a partial response. No side effect was observed. From this case, the possibility that CDDP is able to function as a biochemical modulator for 5-FU was suggested.
一名66岁主诉吞咽困难的男性被诊断为晚期食管癌。食管钡餐检查显示食管在Ei处有一段10厘米长的狭窄（3型），内镜检查时病变部位的活检标本显示为腺鳞癌。CT扫描检测到多处淋巴结转移。他接受了低剂量5-氟尿嘧啶（5-FU）和低剂量顺铂（CDDP）联合治疗。治疗方案为5-FU（300毫克/体/天持续输注）和顺铂（10毫克/体/天持续输注），共3周。经过2个疗程的该方案治疗后，他的症状消失，食管钡餐检查仅显示食管壁有轻度不规则。治疗效果评估为部分缓解。未观察到副作用。从该病例推测，顺铂有可能作为5-氟尿嘧啶的生化调节剂发挥作用。
