Buckley D A, Healy E, Rogers S
City of Dublin Skin and Cancer Hospital, Ireland.
Br J Dermatol. 1995 Sep;133(3):417-22. doi: 10.1111/j.1365-2133.1995.tb02670.x.
The most frequent PUVA treatment regimen in current use is three times weekly, using skin typing to estimate the starting dose. Recently, it was suggested that twice-weekly treatment, using the minimal phototoxic dose (MPD) to calculate suberythemal starting doses of UVA, achieved similar clearance rates with fewer treatments and a lower cumulative UVA dose. We have carried out a trial on 83 patients, comparing twice-weekly MPD-PUVA with three times-weekly skin typing-PUVA, in order to test this hypothesis. Although clearance rates were comparable between the two regimens, there was no overall significant difference in the number of treatments or in the cumulative UVA doses at clearance. However, for patients with skin types I and II the cumulative UVA dose was significantly higher using the twice-weekly MPD regimen (70.0 J/cm2 vs. 55.8 J/cm2; P < 0.05). Our results do not confirm that there is a reduction in cumulative UVA dosage with twice-weekly MPD-PUVA.
目前常用的补骨脂素加长波紫外线（PUVA）治疗方案是每周三次，根据皮肤分型来估算起始剂量。最近，有人提出每周两次的治疗方案，即使用最小光毒剂量（MPD）来计算亚红斑量的UVA起始剂量，该方案在治疗次数更少、累积UVA剂量更低的情况下能达到相似的清除率。我们对83名患者进行了一项试验，比较每周两次的MPD-PUVA方案与每周三次的皮肤分型-PUVA方案，以验证这一假设。尽管两种方案的清除率相当，但在治疗次数或清除时的累积UVA剂量方面，总体上没有显著差异。然而，对于I型和II型皮肤的患者，使用每周两次的MPD方案时累积UVA剂量显著更高（70.0 J/cm²对55.8 J/cm²；P<0.05）。我们的结果并未证实每周两次的MPD-PUVA方案能降低累积UVA剂量。
