通过P58/NKR对HLA.C等位基因的负向信号传导。
Negative signalling via the P58/NKR for HLA.C alleles.
作者信息
Vitale M, Sivori S, Sanseverino L, Barbaresi M, Morelli L, Olcese L, Agugliano R, Bottino C, Moretta A
机构信息
C.B.A. Serv. Immunolopatologia, Genova, Italy.
出版信息
Eur J Histochem. 1994;38 Suppl 1:69-76.
Recent studies have demonstrated that the interaction between HLA class I alleles and specific NK receptors results in negative signals which inhibit NK-mediated cytotoxicity. Such NK receptors have been identified by GL183 and EB6 mAbs which recognize distinct members of a molecular family involved in the recognition of two groups of HLA.C alleles. Now we describe a new allospecific NK group (group 0) which recognize all HLA.C alleles and we demonstrate that, on these clones, the p58 molecules EB6 and GL183 act independently to recognize Cw4 (and related alleles) and Cw3 (and related alleles) respectively. Finally we investigate whether the inhibitory signal mediated by the NK-receptor for HLA.C induce a temporary turn off on the cytolytic activity.
最近的研究表明，HLA I类等位基因与特定NK受体之间的相互作用会产生抑制NK介导的细胞毒性的负信号。此类NK受体已由GL183和EB6单克隆抗体鉴定出来，它们识别参与识别两组HLA.C等位基因的一个分子家族的不同成员。现在我们描述了一个新的同种异体特异性NK组（0组），其识别所有HLA.C等位基因，并且我们证明，在这些克隆上，p58分子EB6和GL183分别独立发挥作用以识别Cw4（及相关等位基因）和Cw3（及相关等位基因）。最后，我们研究了由针对HLA.C的NK受体介导的抑制信号是否会导致细胞溶解活性的暂时关闭。
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