Clarke K, Szer J, Shelton M, Coghlan D, Grigg A
Bone Marrow Transplant Service, Royal Melbourne Hospital, Australia.
Bone Marrow Transplant. 1995 Nov;16(5):723-6.
The successful use of granulocyte transfusions in a patient undergoing volunteer unrelated donor BMT for very severe aplastic anemia complicated by presumed fungal infection is described. Granulocytes were obtained by leukapheresis of normal volunteer donors stimulated by granulocyte colony-stimulating factor. The yields of granulocytes obtained by this method were sufficient to produce sustained neutrophil increments in the recipient throughout the transplant course. In vitro studies indicated that granulocytes were functionally normal, a finding which was supported clinically by the rapid resolution of infection, even in the setting of immunosuppression post-transplantation. This demonstrated the potential value of granulocyte transfusions in high-risk BMT.
本文描述了在一名接受志愿无关供体骨髓移植治疗极重型再生障碍性贫血并伴有疑似真菌感染的患者中成功使用粒细胞输注的情况。粒细胞通过对受粒细胞集落刺激因子刺激的正常志愿供体进行白细胞单采获得。通过这种方法获得的粒细胞产量足以在整个移植过程中使受者的中性粒细胞持续增加。体外研究表明粒细胞功能正常，这一发现得到了临床上感染迅速消退的支持，即使在移植后免疫抑制的情况下也是如此。这证明了粒细胞输注在高危骨髓移植中的潜在价值。
