Pflieger H, Arnold R, Dietrich M, Goldmann S F, Niethammer D
Helv Paediatr Acta. 1977 Sep;32(3):241-9.
A bone marrow transplantation (BMT) was successfully carried out in a seven-year-old boy with aplastic anaemia. An HLA and MLC-identical brother served as donor. During the first 16 days after BMT between 0.55 and 7.11X10(10) granulocytes were transfused 14 times (an average of 4.03X10(10) per transfusion). The maximum increment in the peripheral blood after transfusion was over 4000 granulocytes per microliter. The course of local infections was taken as parameter for determining the clinical effectiveness of the granulocyte transfusion. Under the substitution therapy the necrotic ulcer of a fingertip and the mucous membrane ulcers in the oral cavity subsided. The presence of transfused granulocytes in the oral cavity ("orogranulocytes") could be established. There was a statistically significant relationship between the number of granulocytes in the peripheral blood and the number of orogranulocytes. It could be demonstrated that in children a temporary normalisation of the number of granulocytes in the peripheral blood can be attained by means of granulocyte substitution and that the transfused granulocytes are clinically effective.
对一名患有再生障碍性贫血的7岁男孩成功进行了骨髓移植（BMT）。一名HLA和MLC匹配的兄弟作为供体。在骨髓移植后的前16天内，共输注粒细胞14次，数量在0.55×10¹⁰至7.11×10¹⁰之间（每次输注平均为4.03×10¹⁰）。输血后外周血中粒细胞的最大增幅超过每微升4000个。以局部感染的病程作为判断粒细胞输注临床效果的参数。在替代疗法下，指尖的坏死性溃疡和口腔黏膜溃疡消退。证实了口腔中存在输注的粒细胞（“口粒细胞”）。外周血中粒细胞数量与口粒细胞数量之间存在统计学上的显著关系。可以证明，通过粒细胞替代，儿童外周血中粒细胞数量可暂时恢复正常，且输注的粒细胞具有临床疗效。
