正电子发射断层扫描在药物评估中的应用：三种不同儿茶酚-O-甲基转移酶抑制剂对恒河猴体内[18F]6-氟-L-多巴代谢的影响
Positron emission tomography in drug evaluation: influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-L-dopa in rhesus monkey.
作者信息
Günther I, Psylla M, Reddy G N, Antonini A, Vontobel P, Reist H W, Zollinger A, Nickles R J, Beer H F, Schubiger P A
机构信息
PET Department, Paul Scherrer Institute, Villigen PSI, Switzerland.
出版信息
Nucl Med Biol. 1995 Oct;22(7):921-7. doi: 10.1016/0969-8051(95)00032-s.
We compared the influence of three different catechol-O-methyltransferase (COMT) inhibitors (CGP 28014, OR-611 and Ro 40-7592) on the metabolism of no-carrier-added (NCA) 6-[18F]fluoro-L-dopa (6-FDOPA) in one Rhesus monkey. All three COMT inhibitors improved 6-FDOPA availability in plasma, increased the specific uptake in the brain and thus improved 6-FDOPA uptake measurements using positron emission tomography (PET). Best results were obtained with Ro 40-7592.
我们比较了三种不同的儿茶酚-O-甲基转移酶（COMT）抑制剂（CGP 28014、OR-611和Ro 40-7592）对一只恒河猴体内无载体添加（NCA）的6-[18F]氟-L-多巴（6-FDOPA）代谢的影响。所有这三种COMT抑制剂均提高了血浆中6-FDOPA的可用性，增加了大脑中的特异性摄取，从而改善了使用正电子发射断层扫描（PET）进行的6-FDOPA摄取测量。使用Ro 40-7592获得了最佳结果。
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