Wang A Y, Liu R S
Department of Radiological Technology, Yuanpei Junior College of Medical Technology, Hsinchu City, Taiwan, R.O.C.
Nucl Med Biol. 1995 Oct;22(7):937-42. doi: 10.1016/0969-8051(95)00045-y.
Cysteine was chelated with 99mTc and/or 99Tc in a freeze-dried kit containing Tin(II) ions, and the yellow 99m/99Tc-cysteine complex (complex I) was separated to study the biodistribution. Comparison of the distribution of 99m/99Tc-cysteine and 99mTc-cysteine complexes was made in rats and mice. The renal excretion patterns were studied in rats in the presence and absence of the renal tubular transport inhibitor 2,4-dinitrophenol. The carrier of Tc-cysteine complex in the blood and also the radioactive compounds in the urine were studied by HPGFC and SDS-electrophoresis. The kidney was confirmed as the target organ; serum albumin serves as a carrier for transport of Tc-cysteine complex to the kidney. The Tc-cysteine complex was the primary form in excreta, and glomerular filtration was the dominant excretory pathway.
在含有锡（II）离子的冻干试剂盒中，半胱氨酸与99mTc和/或99Tc螯合，分离出黄色的99m/99Tc-半胱氨酸络合物（络合物I）以研究其生物分布。在大鼠和小鼠中比较了99m/99Tc-半胱氨酸和99mTc-半胱氨酸络合物的分布。在存在和不存在肾小管转运抑制剂2,4-二硝基苯酚的情况下，在大鼠中研究了肾脏排泄模式。通过高效凝胶过滤色谱法（HPGFC）和十二烷基硫酸钠-聚丙烯酰胺凝胶电泳（SDS-电泳）研究了血液中Tc-半胱氨酸络合物的载体以及尿液中的放射性化合物。肾脏被确认为靶器官；血清白蛋白作为将Tc-半胱氨酸络合物转运至肾脏的载体。Tc-半胱氨酸络合物是排泄物中的主要形式，肾小球滤过是主要的排泄途径。
