Kreeger L, Cowin P, Noble-Gresty J, Naysmith A
Pembridge Palliative Care Unit, Charing Cross Hospital, Royal Marsden Hospital, London, UK.
Palliat Med. 1995 Oct;9(4):315-8. doi: 10.1177/026921639500900406.
Diamorphine and bupivacaine are commonly used together for spinal analgesia, although stability data relating to the mixture of the two drugs have not actually been established. We therefore performed a stability study using high performance liquid chromatography for both drugs and the British Pharmacopoeia 2,6-dimethylaniline limit test for bupivacaine, over a period of eight days and at room temperature. Diamorphine and bupivacaine were combined in various concentrations in 100 ml bags for use with the Bard patient controlled analgesia pump. We found no significant change in concentration of either drug, and the 2,6-dimethylaniline limit test was well within set limits. We therefore conclude that it is safe to combine these two drugs in this way.
二醋吗啡和布比卡因通常一起用于脊髓镇痛，尽管关于这两种药物混合物的稳定性数据尚未实际确定。因此，我们使用高效液相色谱法对两种药物进行了稳定性研究，并在室温下进行了为期八天的布比卡因英国药典2,6 - 二甲基苯胺限度试验。二醋吗啡和布比卡因以不同浓度混合在100毫升袋中，用于巴德患者自控镇痛泵。我们发现两种药物的浓度均无显著变化，且2,6 - 二甲基苯胺限度试验完全在设定限度内。因此，我们得出结论，以这种方式将这两种药物混合是安全的。
