神经生长因子促进正常大鼠的条件性味觉厌恶学习。

Nerve growth factor facilitates conditioned taste aversion learning in normal rats.

作者信息

Lipinski W J, Rusiniak K W, Hilliard M, Davis R E

机构信息

Department of Psychology, Eastern Michigan University, Ypsilanti 48197, USA.

出版信息

Brain Res. 1995 Sep 18;692(1-2):143-53. doi: 10.1016/0006-8993(95)00673-e.

DOI:10.1016/0006-8993(95)00673-e

PMID:8548298

Abstract

Chronic intracerebroventricular (i.c.v.) infusion of 3.2 micrograms/day of nerve growth factor (NGF) in normal rats elevated choline acetyltransferase (ChAT) activity of the striatum, medial septum, and basal forebrain and improved performance of a conditioned taste aversion (CTA) task. Relative to bovine serum albumin (BSA) or Cytochrome C treatments, NGF treatment facilitated acquisition and prolonged extinction of a lithium chloride (LiCl)-induced saccharin aversion. This facilitation was evident at saccharin/LiCl intervals ranging up to 1 h. Also, NGF treatment did not increase reactivity to LiCl-induced illness and neither shifted detection thresholds nor altered hedonic reactions to taste stimuli, indicating that NGF did not produce simple changes in sensory function. NGF treatments that elevate ChAT also facilitate memory of CTA in normal, adult rats.

摘要

在正常大鼠中，每天经脑室内（i.c.v.）注入3.2微克神经生长因子（NGF），可提高纹状体、内侧隔区和基底前脑的胆碱乙酰转移酶（ChAT）活性，并改善条件性味觉厌恶（CTA）任务的表现。相对于牛血清白蛋白（BSA）或细胞色素C处理，NGF处理促进了氯化锂（LiCl）诱导的糖精厌恶的获得并延长了消退时间。这种促进作用在糖精/LiCl间隔长达1小时时很明显。此外，NGF处理并未增加对LiCl诱导疾病的反应性，既未改变检测阈值，也未改变对味觉刺激的享乐反应，表明NGF并未在感觉功能上产生简单变化。提高ChAT的NGF处理也有助于正常成年大鼠对CTA的记忆。