Trujillo J R, Garcìa-Ramos G, Novak I S, Rivera V M, Huerta E, Essex M
Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):23-9.
Neurologic complications associated with human immunodeficiency virus type 1 (HIV-1) infection vary geographically. To understand the pattern of HIV-associated neurologic complications in Mexico, 120 AIDS patients from Mexico City, Mexico, and 500 AIDS patients from Houston, Texas, were studied cross-sectionally and retrospectively. Neurologic, laboratory, imaging, and pathologic examinations identified 40 Mexican patients and 130 U.S. patients with neurologic complications. Whereas AIDS dementia complex was the most common neurologic manifestation in both groups, intracranial tuberculoma was present only in the Mexican population (10%). Primary brain lymphoma was more prevalent in the U.S. population (8.4%). The different findings in the Mexican population likely reflect afflictions common to developing countries--a high prevalence of tuberculosis and a high mortality rate. These conditions preclude complications such as lymphoma, which develop later in the natural course of HIV infection.
与1型人类免疫缺陷病毒（HIV-1）感染相关的神经系统并发症存在地域差异。为了解墨西哥HIV相关神经系统并发症的模式，对来自墨西哥城的120例艾滋病患者和来自得克萨斯州休斯敦的500例艾滋病患者进行了横断面和回顾性研究。通过神经学、实验室、影像学和病理学检查，确定了40例墨西哥患者和130例美国患者有神经系统并发症。尽管艾滋病痴呆综合征在两组中都是最常见的神经学表现，但颅内结核瘤仅出现在墨西哥人群中（10%）。原发性脑淋巴瘤在美国人群中更为普遍（8.4%）。墨西哥人群中的不同发现可能反映了发展中国家常见的疾病——结核病的高患病率和高死亡率。这些情况排除了诸如淋巴瘤等在HIV感染自然病程后期出现的并发症。
