Pulmonary antiallergic and antiinflammatory effects of a novel, orally-active phosphodiesterase IV inhibitor (WAY-127093B) in guinea pigs and rats.

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作者信息

Howell R E, Woeppel S L, Howell D E, Rubin E B, Jenkins L P, Golankiewicz J M, Lombardo L J, Heaslip R J

机构信息

Wyeth-Ayerst Research, Princeton, NJ 08543-8000, USA.

出版信息

Inflamm Res. 1995 Aug;44 Suppl 2:S172-3. doi: 10.1007/BF01778317.

DOI:10.1007/BF01778317

PMID:8548383

Abstract

摘要

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Pulmonary antiallergic and bronchodilator effects of isozyme-selective phosphodiesterase inhibitors in guinea pigs.同工酶选择性磷酸二酯酶抑制剂对豚鼠的肺部抗过敏和支气管扩张作用

J Pharmacol Exp Ther. 1993 Feb;264(2):609-15.

Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram.环磷腺苷特异性磷酸二酯酶抑制剂咯利普兰对豚鼠抗原诱导的支气管收缩和嗜酸性粒细胞浸润的抑制作用。

J Pharmacol Exp Ther. 1993 Jul;266(1):306-13.

Leukotrienes mediate antigen-induced airway hyper-reactivity in guinea pigs.

J Pharmacol Exp Ther. 1994 Jan;268(1):353-8.

Phosphodiesterase-IV inhibition, respiratory muscle relaxation and bronchodilation by WAY-PDA-641.

J Pharmacol Exp Ther. 1994 Feb;268(2):888-96.

Characterization of allergen-induced bronchial hyperresponsiveness and airway inflammation in actively sensitized brown-Norway rats.主动致敏的棕色挪威大鼠中变应原诱导的支气管高反应性和气道炎症的特征

J Allergy Clin Immunol. 1991 Dec;88(6):951-60. doi: 10.1016/0091-6749(91)90253-k.

Effect of acute and chronic antigen inhalation on airway morphology and responsiveness in actively sensitized rats.急性和慢性吸入抗原对主动致敏大鼠气道形态和反应性的影响。

Am Rev Respir Dis. 1992 Jun;145(6):1306-10. doi: 10.1164/ajrccm/145.6.1306.

Model of bronchial allergic inflammation in the brown Norway rat. Pharmacological modulation.

Int J Immunopharmacol. 1992 Jul;14(5):847-55. doi: 10.1016/0192-0561(92)90083-w.

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