Sub-therapeutic doses of sirolimus and cyclosporin A in combination reduce SLE pathologies in the MRL mouse.

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超能文献

作者信息

Warner L M, Cummons T, Nolan L, Sehgal S N

机构信息

Inflammatory Diseases Division, Wyeth-Ayerst Research, Princeton, NJ 08543, USA.

出版信息

Inflamm Res. 1995 Aug;44 Suppl 2:S205-6. doi: 10.1007/BF01778335.

DOI:10.1007/BF01778335

PMID:8548401

Abstract

摘要

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Clinical Experience of Sirolimus Regarding Efficacy and Safety in Systemic Lupus Erythematosus.西罗莫司治疗系统性红斑狼疮的疗效与安全性临床经验

Front Pharmacol. 2019 Feb 6;10:82. doi: 10.3389/fphar.2019.00082. eCollection 2019.

本文引用的文献

Rapamycin prolongs survival and arrests pathophysiologic changes in murine systemic lupus erythematosus.

Arthritis Rheum. 1994 Feb;37(2):289-97. doi: 10.1002/art.1780370219.

Immunoregulation in MRL/Mp-lpr/lpr mice: evidence for decreased helper-T-cell and increased suppressor-T-cell function with age.

Cell Immunol. 1982 Nov 15;74(1):72-85. doi: 10.1016/0008-8749(82)90007-7.

In vitro stimulation of murine spleen cells using a microculture system and a multiple automated sample harvester.使用微量培养系统和多重自动样本采集器对小鼠脾细胞进行体外刺激。

J Immunol Methods. 1973 Apr;2(3):279-91. doi: 10.1016/0022-1759(73)90054-9.

Lymphocyte activation. V. Quantitation of the proliferative responses to mitogens using defined T and B cell populations.淋巴细胞激活。V. 使用特定的T细胞和B细胞群体对有丝分裂原的增殖反应进行定量分析。

Clin Exp Immunol. 1973 Aug;14(4):581-96.

Deletion of potentially self-reactive T cell receptor specificities in L3T4-, Lyt-2- T cells of lpr mice.lpr小鼠L3T4-、Lyt-2-T细胞中潜在自身反应性T细胞受体特异性的缺失。

J Exp Med. 1988 Dec 1;168(6):2221-9. doi: 10.1084/jem.168.6.2221.

Delineation of two defects responsible for T-cell hyporesponsiveness to concanavalin A in MRL congenic mice.确定导致MRL同源小鼠T细胞对刀豆球蛋白A反应低下的两个缺陷。

Immunology. 1986 Oct;59(2):187-93.

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.相关大环内酯类药物FK-506和雷帕霉素对小鼠T细胞活化的不同抑制机制。

J Immunol. 1990 Jan 1;144(1):251-8.

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