O'Brien B L, DiPalma J A
Division of Gastroenterology, University of South Alabama College of Medicine, Mobile 36617, USA.
Dig Dis. 1995 May-Jun;13(3):182-9. doi: 10.1159/000171500.
Molecular genetics has rapidly advanced our understanding of pathogenesis and biologic behavior of colorectal carcinoma. This article will review the genetic changes which occur in colonic mucosa as it progresses from benign to malignant as well as review the inherited forms of colorectal cancer. Current screening methods and anticipated future strategies for colorectal cancer screening will be discussed.
分子遗传学迅速提升了我们对结直肠癌发病机制和生物学行为的理解。本文将回顾结肠黏膜从良性发展为恶性过程中发生的基因变化，以及遗传性结直肠癌的情况。还将讨论结直肠癌目前的筛查方法和预期的未来筛查策略。
