De Filippi C, Regazzini R, Piazza V, Galli F, Pisati P, Sacchi S, Salvadeo A
Dermatology Clinic, IRCCS Policlinico S. Matteo, Pavia, Italy.
Clin Exp Dermatol. 1995 Jul;20(4):294-6. doi: 10.1111/j.1365-2230.1995.tb01328.x.
Pruritus is a common symptom in uraemic patients and its aetiology is poorly understood, although several factors have been implicated, including high histamine plasma levels. The aim of the study was to evaluate plasma levels of histamine in patients on maintenance haemodialysis in relation to the presence of itching (35 pruritic patients = group A; 50 non-pruritic patients = group B). Furthermore, we compared the values obtained with those of a healthy control group (64 subjects). We observed increased plasma histamine levels in uraemic patients compared with healthy controls. However, no relationship was found between plasma histamine values and itching because groups A and B showed overlapping values and there was no correlation between the intensity of pruritus and plasma histamine concentrations in group A patients. In conclusion, we suggest that there is no evidence for plasma histamine playing a significant part in uraemic pruritus.
瘙痒是尿毒症患者的常见症状，尽管已有多种因素被认为与瘙痒有关，包括血浆组胺水平升高，但其病因仍不太清楚。本研究的目的是评估维持性血液透析患者的血浆组胺水平与瘙痒的关系（35例瘙痒患者=A组；50例无瘙痒患者=B组）。此外，我们将所得值与健康对照组（64名受试者）的值进行了比较。我们观察到，与健康对照组相比，尿毒症患者的血浆组胺水平升高。然而，血浆组胺值与瘙痒之间未发现相关性，因为A组和B组的值有重叠，且A组患者的瘙痒强度与血浆组胺浓度之间无相关性。总之，我们认为没有证据表明血浆组胺在尿毒症瘙痒中起重要作用。
