Arias J, Férnandez-Rivas M, Panadero P
Allergy Section, Hospital Virgen del Valle, Toledo, Spain.
Clin Exp Dermatol. 1995 Jul;20(4):339-40. doi: 10.1111/j.1365-2230.1995.tb01338.x.
A selective fixed drug eruption to amoxycillin but not other betalactam drugs is reported. Penicillins are the drugs most frequently implicated in immunological adverse reactions. The most important of these are allergic reactions where an IgE-mediated mechanism is well established. Other immunological mechanisms have been described in reactions, such as haemolytic anaemia, serum sickness, drug-induced nephritis, drug fever and contact dermatitis. Fixed drug eruption (FDE) is a type of drug-induced dermatosis, the immunopathogenesis of which remains unknown. FDE is an uncommon reaction to penicillin derivatives, and very few cases have been reported. We present a case of a selective FDE to amoxycillin (AX), with no reaction to other betalactam drugs. Although one similar case has been reported, the reactivity to other penicillin derivatives was not assessed.
据报道，存在对阿莫西林而非其他β-内酰胺类药物的选择性固定性药疹。青霉素是最常引发免疫不良反应的药物。其中最重要的是过敏反应，IgE介导机制已得到充分证实。在诸如溶血性贫血、血清病、药物性肾炎、药物热和接触性皮炎等反应中，还描述了其他免疫机制。固定性药疹（FDE）是一种药物性皮肤病，其免疫发病机制尚不清楚。FDE是对青霉素衍生物的一种罕见反应，仅有极少数病例报道。我们报告一例对阿莫西林（AX）的选择性FDE病例，对其他β-内酰胺类药物无反应。尽管已有一例类似病例报道，但未评估对其他青霉素衍生物的反应性。
