抑肽酶对慢性缺氧大鼠肾功能的影响。

Effects of aprotinin on renal function in chronic hypoxic rats.

作者信息

Chen C F, Chen L W, Chien C T

机构信息

Department of Physiology, College of Medicine, National Taiwan University, Taipei, ROC.

出版信息

Chin J Physiol. 1995;38(1):23-6.

PMID:8549232

Abstract

The effect of aprotinin, a nonspecific kallikrein inhibitor on renal function was studied in chronic hypoxic rats (high altitude, HA), comparing to control rats kept at sea level (SL). Hypoxia was induced by placing female Wistar rats (195-230 g) in an altitude chamber (5,500 m) 15 hr per day for 4 weeks. Intrarenal arterial administration of aprotinin (300 kiu/kg/min), reduced the urinary kallikrein activity (UKA) in 9 SL and 10 HA anesthetized rats. Aprotinin did not significantly alter the urinary excretion of urine, sodium and potassium in SL rats, however, those parameters increased after aprotinin administration in HA rats. These data support the hypothesis that kallikrein participates in the regulation of renal function in chronic hypoxic rats.

摘要

研究了非特异性激肽释放酶抑制剂抑肽酶对慢性缺氧大鼠（高海拔，HA）肾功能的影响，并与饲养在海平面（SL）的对照大鼠进行比较。通过将雌性Wistar大鼠（195 - 230克）每天置于海拔舱（5500米）15小时，持续4周来诱导缺氧。对9只SL和10只HA麻醉大鼠进行肾内动脉注射抑肽酶（300 kiu/kg/分钟），降低了尿激肽释放酶活性（UKA）。抑肽酶对SL大鼠的尿、钠和钾排泄没有显著影响，然而，在HA大鼠中注射抑肽酶后这些参数增加。这些数据支持激肽释放酶参与慢性缺氧大鼠肾功能调节的假说。