Takamatsu N, Shiba T, Muramoto K, Kamiya H
Department of Biosciences, School of Science, Kitasato University, Kanagawa, Japan.
FEBS Lett. 1995 Dec 27;377(3):373-6. doi: 10.1016/0014-5793(95)01375-X.
Aplysianin-A, an antibacterial glycoprotein in the albumen gland of the sea hare Aplysia kurodai, inhibited the growth of both Gram-positive and Gram-negative bacteria. Aplysianin-A cDNA clones were isolated from an albumen gland cDNA library. Sequence analysis reveals that aplysianin-A is produced as a precursor protein of 556 amino acid residues with a signal peptide of 19 amino acid residues and contains 6 potential N-glycosylation sites. Aplysianin-A mRNA was expressed tissue-specifically in the albumen gland. Homology search reveals that aplysianin-A has a 50% overall amino acid sequence homology to achacin, an antibacterial glycoprotein of the giant African snail Achatina fulica.
海兔素 - A是黑指纹海兔蛋白腺中的一种抗菌糖蛋白，可抑制革兰氏阳性菌和革兰氏阴性菌的生长。从蛋白腺cDNA文库中分离出海兔素 - A的cDNA克隆。序列分析表明，海兔素 - A以前体蛋白的形式产生，该前体蛋白含有556个氨基酸残基，带有一个19个氨基酸残基的信号肽，并且含有6个潜在的N - 糖基化位点。海兔素 - A的mRNA在蛋白腺中呈组织特异性表达。同源性搜索显示，海兔素 - A与非洲大蜗牛的抗菌糖蛋白玛瑙螺毒素在整体氨基酸序列上有50%的同源性。
