人类REG家族基因在2号染色体p12区域的一个95千碱基区域中串联排列。
Human REG family genes are tandemly ordered in a 95-kilobase region of chromosome 2p12.
作者信息
Miyashita H, Nakagawara K, Mori M, Narushima Y, Noguchi N, Moriizumi S, Takasawa S, Yonekura H, Takeuchi T, Okamoto H
机构信息
Department of Biochemistry, Tohoku University School of Medicine, Miyagi, Japan.
出版信息
FEBS Lett. 1995 Dec 27;377(3):429-33. doi: 10.1016/0014-5793(95)01381-4.
Reg, first isolated from a rat regenerating islet cDNA library, is expressed in regenerating islet beta-cells. Recently, it has been revealed that Reg and Reg-related genes constitute a multigene family, the Reg family. In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated. In this study, we analyzed YAC clones containing the four genes and performed two-color FISH to determine the map order of the genes. The human REG family genes are tandemly ordered in the 95-kbp DNA region of chromosome 2p12 as follows: 2cen-HIP/PAP-RS-REG I alpha-REG I beta-ptel.
Reg最初是从大鼠再生胰岛cDNA文库中分离出来的，在再生胰岛β细胞中表达。最近发现，Reg和Reg相关基因构成了一个多基因家族，即Reg家族。在人类中，目前已分离出四个REG家族基因，即REG 1α、REG 1β、Reg相关序列（RS）和HIP/PAP。在本研究中，我们分析了包含这四个基因的酵母人工染色体（YAC）克隆，并进行了双色荧光原位杂交（FISH）以确定这些基因的图谱顺序。人类REG家族基因在2号染色体p12区域的95千碱基对（kbp）DNA区域中串联排列如下：2号染色体着丝粒-HIP/PAP-RS-REG Iα-REG Iβ-染色体末端。
Zotero 插件