Shaw C J, Spencer J D
Guy's Hospital, London, UK.
Injury. 1995 Nov;26(9):633-5. doi: 10.1016/0020-1383(95)00112-m.
Four patients have presented secondarily to this unit in recent years with rhabdomyolysis following prolonged compartment syndromes consequent upon drug overdoses or severe injury. Multiple complications arose due to the severe nature of the compartment syndrome itself and also its late and sometimes incomplete initial treatment. In two cases out of four a secondary amputation was required. Our experience with these cases demonstrates the importance of repeat examination under anaesthetic of the affected limbs following fasciotomy, even if apparently healthy granulation tissue is forming, and the value of persistent oedema and elevated creatine phosphokinase levels as markers of continued pathology. Observation of these factors may enable amputations and prolonged nerve palsies to be avoided in future patients.
近年来，有4名患者因药物过量或严重损伤导致长时间骨筋膜室综合征后继发横纹肌溶解症，继而转入本科室。由于骨筋膜室综合征本身病情严重，且初始治疗延迟、有时不彻底，出现了多种并发症。4例中有2例需要进行二期截肢。我们对这些病例的经验表明，即使形成了看似健康的肉芽组织，在筋膜切开术后仍需在麻醉下对患肢进行重复检查，持续性水肿和肌酸磷酸激酶水平升高作为持续病变的标志物具有重要意义。观察这些因素可能有助于避免未来患者出现截肢和长期神经麻痹的情况。
