Van Eenennaam A L, Gardner I A, Holmes J, Perani L, Anderson R J, Cullor J S, Guterbock W M
University of California, Davis 95616, USA.
J Dairy Sci. 1995 Sep;78(9):2086-95. doi: 10.3168/jds.S0022-0302(95)76835-7.
For two large California dairy herds with twice daily milking, 171 infected quarters of lactating cows with mild clinical mastitis were randomly assigned to one of three treatment groups. Group A (50 cows) was treated with 62.5 mg of intramammary amoxicillin every 12 h for three milkings. Group C (50 cows) was treated with 200 mg of intramammary cephapirin every 12 h for two milkings. Group O (71 cows) was treated with 100 U of intramuscular oxytocin every 12 h for three milkings. Clinical cure rates did not differ among treatment groups. The cost per episode of clinical mastitis was higher ($54.47) for group C than for groups A ($38.53) or O ($34.88). Group O had a higher incidence of relapse (41%), and a greater percentage of group O cows (65%) experienced an additional mastitic event in the enrolled lactation than did cows in groups A and C. Treatment had no effect on the mean number of nonsalable milkings (24.7) associated with mastitis in the lactation interval subsequent to enrollment on the trial. Twenty-two percent of the cows accrued more than 30 nonsalable milkings and produced 55% of the total nonsalable milkings associated with mastitis. There was no treatment effect on total milk production, fat production, or time to removal of the enrolled cows from the herd.
对于加利福尼亚州的两个大型奶牛场，奶牛每天挤奶两次，将171头患有轻度临床型乳腺炎的泌乳期奶牛感染的乳腺随机分配到三个治疗组之一。A组（50头奶牛）每12小时经乳房内注射62.5毫克阿莫西林，共进行三次挤奶治疗。C组（50头奶牛）每12小时经乳房内注射200毫克头孢匹林，共进行两次挤奶治疗。O组（71头奶牛）每12小时肌肉注射100单位催产素，共进行三次挤奶治疗。各治疗组的临床治愈率无差异。C组临床型乳腺炎每发作一次的成本（54.47美元）高于A组（38.53美元）或O组（34.88美元）。O组的复发率较高（41%），与A组和C组的奶牛相比，O组有更高比例（65%）的奶牛在登记的泌乳期发生了额外的乳腺炎事件。在试验登记后的泌乳期，治疗对与乳腺炎相关的不可销售挤奶的平均次数（24.7次）没有影响。22%的奶牛积累了超过30次不可销售的挤奶，这些奶牛产生了与乳腺炎相关的不可销售挤奶总量的55%。在总产奶量、脂肪产量或登记奶牛从牛群中被淘汰的时间方面，治疗没有效果。
