Byk T, Dobransky T, Cifuentes-Diaz C, Sobel A
Institut National de la Santé et de la Recherche Médicale, Paris, France.
J Neurosci. 1996 Jan 15;16(2):688-701. doi: 10.1523/JNEUROSCI.16-02-00688.1996.
The control of neuritic extension and guidance is critical for the development, maturation, and regeneration of functional neuronal circuits. We identified a neuronal 64-85 kDa phosphoprotein, the expression of which in mouse brain is regulated during development, reaching a peak at approximately 5 d postnatal, when maturation of neurons and synaptic connections is highly active. The amino acid sequence of the mouse protein deduced from its cloned cDNA reveals similarities with that of the neuritic outgrowth- and guidance-related product of the unc-33 gene in Caenorhabditis elegans. The regulation of its phosphorylation in response to nerve growth factor, as well as its localization in neurites and growth cones and at the neuromuscular junction, further indicates that Ulip (for Unc-33-like phosphoprotein) is not only a structural but likely is also a functional mammalian homolog of Unc-33, potentially involved in the control of neuritic outgrowth and axonal guidance.
神经突延伸和导向的控制对于功能性神经回路的发育、成熟和再生至关重要。我们鉴定出一种神经元64 - 85 kDa磷蛋白，其在小鼠脑中的表达在发育过程中受到调控，在出生后约5天时达到峰值，此时神经元和突触连接的成熟高度活跃。从小鼠蛋白克隆的cDNA推导的氨基酸序列显示与秀丽隐杆线虫unc - 33基因的神经突生长和导向相关产物相似。其磷酸化对神经生长因子的响应调控，以及其在神经突、生长锥和神经肌肉接头处的定位，进一步表明Ulip（类Unc - 33磷蛋白）不仅是Unc - 33的结构同源物，而且可能也是功能同源物，可能参与神经突生长和轴突导向的控制。
